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Increasing the dose of RTV does not overcome this interaction and may increase hepatotoxicity. Increasing the COBI dose is not recommended. Consider rifabutin if a rifamycin is indicated.

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The major circulating metabolite is the methylcatechol glucuronide, which is 13, times less potent for PDE5 than tadalafil. The mean elimination half-life is After a single oral dose, the maximum observed plasma concentration Cmax occurs Generic Levitra 30 minutes and 6 hours Tmax median time 2 hours. The usual onset of action is within 30 to 45 minutes, and the usual duration is up to 36 hours.

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